Target stress-induced hair-loss
with Prunizen™ from Clariant

− Targets psychoemotional stress-triggered cortisol production known to weaken hair
− Clinical performance on anti-hair loss activity after 3 months
− Provides better hair vitality & soothes scalp discomfort
Clariant Natural Ingredients announces the launch of Prunizen a new natural “feel good” active to
fight stress-induced hair-loss, improve hair vitality and density, and restore hair and scalp wellbeing. The extract of Prunella vulgaris, an edible and traditional medicinal plant commonly known
as “self-heal”, will make its industry debut at in-cosmetics Global 2022.
Psychoemotional stress (PES) is caused by personal pressures, situations, and life experiences
and is unfortunately commonly felt. On-going uncertainty, as in current times, can heighten its
presence. According to a new survey conducted by Clariant1
, more than 70% of consumers feel
stressed. They have a thorough knowledge of the effects of stress, and 86% are aware of the
negative impact it can have on appearance. Damage to hair is a prime consumer concern, and
hair loss is the number one stress manifestation they cite.
“PES is deeply detrimental to scalp and hair health because it triggers excessive production of the
hormone cortisol. This provokes negative reactions such as accelerated hair loss, thinning,
graying, scalp irritation and itching. It’s not possible to eliminate PES periods from people’s lives,
but we are delighted to offer a herbal active proven to uniquely reduce stress-induced changes,
which will support anti-hair-loss innovation and the growing role of haircare products in managing
emotional strain,” comments Alexandre Lapeyre, Head of Marketing & Business Development
Clariant Natural Ingredients.
Prunizen utilizes the properties of Prunella vulgaris to successfully help reduce cortisol production.
In destressing the hair and scalp, the new extract efficiently counteracts stress-induced slowing of
hair follicles growth, helps preventing hair fall, and protects hair structure. It also improves the
scalp’s well-being by increasing the release of oxytocin, a powerful neurotransmitter that provides
potent anti-stress effects.
Clinical tests demonstrate its positive effects in fighting stress-induced hair loss and visibly
improving hair density in emotionally stressed people. After three months, the volunteers benefited
from -15% reduction in hair in loss stage, +83% increase in hair quality and +38% increase in hair
1 Survey of 300 average French consumers (269 women/31 men, aged 20-60)
Target stress-induced hair-loss
with Prunizen™ from Clariant
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In light of its effectiveness and natural origin composition, Prunizen is set to be a particularly
welcome innovation for formulators and brands as demand for sophisticated high-end hair care
steps up.
To discover more about potential applications, test results, and inspiration for developing novel
hair and scalp care products targeting cortisol’s negative effects, visit
Prunizen will be showcased at in-cosmetics 2022 Booth E70 in an exciting sample formulation
within Clariant’s new Beauty Wizard concept. And features in a presentation “Natural actives to
tackle the effects of contemporary stress” on April 5, 17:20 h – 17:50 h in Theatre 3.
Find out more about Clariant’s support for more sustainable, high RCI formulations that inspire
consumers at Booth E70 and across the in-cosmetics event in a series of technical seminars and
at the Innovation Showcase. Full details of topics and timings can be accessed via

Prunizen, an extract of Prunella vulgaris, based on the edible and traditional medicinal herb cultivated in Asia and Europe to fight
inflammation and oxidative stress.

By targeting the main stress mediator cortisol and its downstream activation, scalp homeostasis should be preserved, and hair loss